How to get Caliban Prime Relics in Warframe

Image via Digital Extremes

Published: Aug 26, 2025 01:14 pm

Caliban Prime has finally arrived in Warframe, and fans of the Sentient Sovereign have even more to celebrate after his first Deluxe skin and a minor rework.

As usual, Caliban Prime comes with a shiny new look, boasting slightly improved stats and more polarities compared to his default version. The summoner works as a potentially great controller and support, boosting allies’ shields and with a great area-of-effect armor strip and debuffs—and that’s without touching on the potential for Helminth abilities.

Here are all Caliban Prime Relics and our favorite locations to get them in Warframe.

All Caliban Prime Relics in Warframe

Caliban Prime holds his signature sniper rifle, Vadarya Prime. — The Vadarya Prime doesn’t look bad either. Image via Digital Extremes

Caliban Prime’s Relics include two Lith Relics, one with the rare Neuroptics and the common Chassis. You also need to farm Meso and Axi Relics to unlock Caliban Prime, but you don’t need Neo Relics this time around.

Lith C13—Neuroptics (Rare)
Lith K12—Chassis (Common)
Meso V11—Blueprint (Uncommon)
Axi C10—Systems (Rare)

Best spots to farm Caliban Prime Relics in Warframe

Caliban Prime and his signature Syandana. — His signature Syandana may not show up on the in-game market. Image via Digital Extremes

We’ve been using these locations to farm Primes for years, and they’re bound to work well if you’d like to add Caliban Prime to your arsenal.

Part/Relic	Mission Type/Location	Notes
Lith	Hepit, Void (Capture)	Capture missions are the quickest mission type in Warframe (sometimes even if they turn into Exterminations), and this one guarantees you’ll get either a Lith Relic or Aya, with a 6.67 percent chance of getting the item you need.
Meso	Io, Jupiter (Defense)	Io is guaranteed to drop a Meso Relic on Rotation A. Thanks to the shortening of Defense missions, you have a 12.5 percent chance of getting a Meso V11 at wave three and that same chance at wave six, so reset after that for best results.
Axi	Apollo, Lua (Disruption)	With a guaranteed Axi on Rotation B and high chances of one in Rotation C, you can continue to farm this Disruption to stock up on Axi Relics as long as you keep manipulating the outcomes to your liking.

The rotation list for Disruption is as follows, based on the official Wiki.

The official rewards table for Disruption, as listed on the Wiki. — How to play the Disruption rewards in your favor. Screenshot by Destructoid via Warframe Wiki

To grab Axi Relics for Caliban Prime, sticking to rotation B is the play. Defend all four conduits on the first wave, then you can either save them all or lose one in the second wave. From there, lose one on wave three and lose at least two in the fourth wave and beyond. You can also just reset after a couple of rounds, since it might be easier.

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